General presentation

The YALES2BIO project leaded by S. Mendez and F. Nicoud aims at developing an efficient and reliable numerical software for the analysis of medical devices in contact with blood such as flow diverters, Ventricular Assist Devices, extra corporal circulation, artificial heart and valves, cytometers among others. Optimizing such devices requires dealing with both macroscopic (pressure loss, residence time, wall shear stress, turbulence) and microscopic (blood cells deformation and interaction with other cells or solid boundaries) features. YALES2BIO inherits its massively parallel capabilities and high order finite volumes schemes for complex geometries from the YALES2 solver developed at CORIA (UMR CNRS 6614). Specific models for handling both macroscopic and microscopic blood flows are being developed, implemented and validated within the cardiovascular group at IMAG (UMR CNRS 5149). The Fluid-Structure Interaction problem which describes the deformation of the membrane of the red blood cell is solved thanks to a front-tracking / Immersed Boundary Method suitable for unstructured meshes. YALES2BIO can also be coupled with the LMGC90 structural solver when complex material rheology must considered. Contrary to many other methods, the YALES2BIO approach does not assume Stokes regime but solves the complete Navier-Stokes equations inside and outside the cell of interest. Appropriate subgrid-scale models for Large Eddy Simulation of transitional flows are used for accounting for the turbulence effects if present.
Some of the applications covered by the YALES2BIO solver were presented at the French Academy of Sciences in May 2017. See the video (in french)