Séminaire de Probabilités et Statistique
Monday 01 December 2025 à 13:45 - UM, campus Triolet, bâtiment 9, salle 109 (1er étage)
Baldwin Dumortier (IMAG)
Pepline, PeTriBox and Proteins: Protein Inverse Folding and Peptide Generation
In 2021, AlphaFold2 achieved a historic breakthrough by solving a 50-year-old challenge: predicting the 3D structure of a protein from its amino-acid sequence alone. Building on this milestone, we developed PeTriBERT, a model distilled from the AlphaFold database and AlphaFold2 outputs to address the inverse folding problem —predicting a sequence that is structurally compatible with a given conformation.
PeTriBERT enables the generation of novel sequences and serves as a versatile sequence–structure encoder capable of supporting a wide range of protein-related tasks. In particular, our subsequent work introduced:
- Pepline, a peptide generation model,
- PeTriPPI V1 and V2, for protein–protein interaction prediction.
All these models and their derivatives are organized within a unified framework, PeTriBOX, which brings together the different components built around PeTriBERT.
In this presentation, we will briefly introduce PeTriBERT, outline its evolution, and discuss its current limitations.
Séminaire en salle 109, également retransmis sur zoom : https://umontpellier-fr.zoom.us/j/7156708132