Séance Séminaire

Séminaire de Probabilités et Statistique

lundi 09 mai 2022 à 14:00 - UM - Bât 09 - Salle de conférence (1er étage)

Piret Avila (Department of Ecology and Evolution - University of Lausanne)

On life-history and deleterious mutation rate co-evolution and its implications on the evolution of ageing (Séminaire KIM)

The cost of germline maintenance and repair gives rise to a trade-off between immutability (lowering the deleterious mutation rate) and life-history functions. Life-histories and the mutation rate therefore co-evolve, but this joint evolutionary process is not well understood. I present a mathematical model we developed to analyse the long-term evolution of traits affecting life-histories and deleterious mutation rate. I show that evolutionary stable life-histories and mutation rates can be characterised using the basic reproductive number of the least-loaded class (expected lifetime production of offspring without deleterious mutations born to individuals with the smallest number of deleterious mutations). I discuss two specific biological scenarios: (i) co-evolution between reproductive effort and mutation rate and (ii) co-evolution between age at maturity and mutation rate. These two scenarios suggest two results. First, the trade-off between immutability vs life-history functions depends strongly on environmental conditions and baseline mutation rate. For example, low external mortality and high radiation environment favour high investment into immutability. Second, the trade-offs between different life-history factors can be strongly affected by mutation rate co-evolution and higher baseline mutation rates select for "faster life histories": (i) higher investment into fecundity at the expense of survival and (ii) earlier age of maturation at smaller sizes. Finally, I discuss the implications of our model on understanding evolution of ageing.

Séminaire à 14h en salle 109 (IMAG, bâtiment 9).
Également retransmis sur zoom : https://umontpellier-fr.zoom.us/j/94087408185